Here's a ranked listing of Fonts.com Web Fonts' top 100 most used Web fonts for November 2012:
Neue Helvetica
Helvetica
Trade Gothic
Univers
Gill Sans
Neue Frutiger
Avenir
Avenir Next
Futura
DIN Next
Frutiger
ITC Avant Garde Gothic
Linotype Univers
News Gothic
Monotype News Gothic
PMN Caecilia
Trade Gothic Next
Neo Sans
Agilita
Arial
New Century Schoolbook
Linotype Didot
ITC Lubalin Graph
DIN 1451
Neue Haas Grotesk
ITC Franklin Gothic
ITC Garamond
Century Gothic
Univers Next
Frutiger Next
Optima
VAG Rounded
Abadi
Adelle
Twentieth Century
ITC Conduit
Rockwell
Soho
ITC Officina Sans
Garamond 3
Laurentian
Trade Gothic Next Soft Rounded
Neue Helvetica Arabic
ITC Fenice
News Gothic No.2
Eurostile LT
Soho Gothic
Frutiger Serif
ITC Century
Biome
Bauer Bodoni
Sassoon Sans
Candara
Sackers Gothic
Neue Helvetica eText
Harmonia Sans
Calibri
Futura T
Yakout
Times
Glypha
Novecento
MSung
ITC American Typewriter
Albany
ITC Franklin
Helvetica World
Sabon
Clarendon
Slate
Compatil Text
Gazette
Rotis II Sans
Georgia
Akko
Gill Sans Infant
Eurostile Next
Iridium
Georgia Pro
MHei
Monotype Garamond
Heisei Kaku Gothic
Neuzeit Office
Memphis
Bembo
Baskerville
Cachet
Azbuka
Serifa
Museo Slab
Museo Sans
Bodoni LT
ITC Officina Serif
Plantin
Aeris
Monotype Grotesque
CHei2
Basic Commercial
Janson Text
Andy
Ryan Arruda is the Web Content Strategist at Monotype Imaging. Ryan holds a bachelor's degree in film studies from Clark University, and an MFA in graphic design from RISD.